Longevity Diet-1 (LD-1)
Yes, we are raising funds among other things to do the paperwork. But we do not want to wait and, regardless of the result of the ICO, we will continue to work on clinical research. We managed to start the process with the support of the sponsor, and you can already track our work: by September 9, 2017, the Protocol, Synopsis and Informed Consent Form of the study have been prepared; the Brochure and Registration Form are being prepared.
If you want to leave comments directly in the document (we welcome criticism and suggestions from specialists), please contact Anastasia Egorova directly—she will give you access.
Hunger has been a terrible disaster in the history of mankind. Hunger in nature is often detrimental, as it is not metered and is not allowing to obtain good nutrition.

However, short cycles of fasting with subsequent recovery feeding considerably extends lives of rodents and many other model animals. The basic fasting mechanism of life extension in animals is a temporary decrease in the level of insulin-like growth factor of type 1 (IGF-1) to reprogram stem cells with subsequent restoration of IGF-1 for turning reprogrammed stem cells for growth and renewal of tissues.

Not only fasting, but even reduced-calories extended lives of rhesus macaques, but not as much as lives of rodents. Why? In primates and humans, unlike rodents, low-calorie diet does not decrease the level of IGF-1 – it can only be decreased by hunger or reduced amount of animal protein in diet.
Interesting facts
  • Balanced low calorie diet for 2-4 years in Copenhagen and in Norway was associated with reduced human mortality by 20-34%.
  • Cutting calories by 25-30% or fasting has shown reduced mortality in randomized controlled trials in young and elderly.
  • One of the main mechanisms for achieving longevity and protection from cancer during fasting is the reduction of IGF-1 level. So people with Laron-type dwarfism, which is characterized by low level of IGF-1, do not get cancer. Mouse-dwarves with a similar syndrome, live 20-30% longer than average mice and develop cancer at much older age.
  • Ashkenazi Jewish centenarians are known to have defect of the IGF-1 receptor.
So fasting can powerfully extend lifespan of many model animals. But fasting is not convenient. We can't take a 5-days vacation monthly. Plus while starving it's extremely difficult to work, there is a lack of energy.

Longevity Diet-1 (LD-1) may be a safe and effective way to temporarily reduce IGF-1 level without starving. And thus extend human lifespan and postpone a number of dangerous age-related diseases.

Studies have shown that these types of diets extended lifespan of long-living mice; mice improved motor coordination, memory, neurogenesis; reversed (achieved remission) symptoms of multiple sclerosis in 20% of the cases; recovered pancreas cells in a model of type 2 diabetes; reversed type 1 diabetes in the model of induced by streptozotocin type 1 diabetes.

These were all in mice, but diets also improved many markers of aging in clinical trials (human studies).
Other trials
Clinical trials we plan to conduct at the expense of funds collected via ICO.